Antimicrobial Resistance; the next global health challenge

Imagine a future where the simple act of taking antibiotics could be futile, where common infections once easily treated become life-threatening. This is not a distant dystopia; it’s a reality we are inching towards every day due to antimicrobial resistance (AMR). By 2050, AMR could claim 10 million lives annually, surpassing the death toll of diseases like HIV and malaria. Yet, despite its looming threat, AMR remains a silent pandemic, growing in the shadows of our collective consciousness.

Credit: Serkan Yildiz

The disconnect between the public’s understanding of AMR and the gravity of its impact is alarming. Communities contribute to antimicrobial overuse through individual and collective consumption behaviors, such as high antibiotic consumption, which has been reported in high-income as well as low- and middle-income country settings. But is the public truly aware of the dangers of AMR?

AMR occurs when microbes evolve to resist the effects of antimicrobials designed to kill them. This resistance can develop naturally over time, but the overuse and misuse of antimicrobial drugs accelerate the process. The consequences are dire: modern medicine could regress, surgical procedures could become perilous without effective prophylactic antibiotics, and the benefits of globalization could ironically hasten the spread of resistant infections.

To combat AMR, we must promote appropriate use of antimicrobials, requiring a behavioral shift in prescribing and usage. This challenge is not confined to the human health sector but extends to the animal and environmental health sectors, too. A multi-stakeholder approach is essential for effective solutions, with public awareness being a critical component. Communities must be engaged with consistent messaging on accessible platforms tailored to their contexts.

Interventions must target healthcare workers and users to promote appropriate antimicrobial prescribing and use. In regions where antimicrobials are easily accessible, these interventions must balance the need for proper use against the threat of inadequate access, which can pose a greater danger than resistance.

We are racing against time to prevent a return to the pre-antibiotic era, a fight for survival where infectious microbes currently have the upper hand. The clock is ticking, and the time to act is now. We must raise awareness, change behaviors, and implement strategies to ensure that antimicrobials remain effective tools in our medical arsenal.

The future of our health and that of generations to come depends on our collective action today. Let us unite in this cause and work towards a world where AMR is no longer a silent pandemic but a challenge we have overcome together. The change starts here. The change starts with us. We can and must transform our approach to antimicrobial use, ensuring that these life-saving drugs remain potent and effective for all who need them. We cannot do it alone but together, we can be stronger and usher in a bold new era of responsible antimicrobial use and stewardship for the benefit of all global citizens.

Oluchi Mbamalu

Oluchi Mbamalu is a Pharmacist and Researcher in Cape Town, South Africa. She has a keen interest in wider stakeholder engagement to raise awareness of infection risks, especially risks of antimicrobial resistant infections, with a focus on understanding barriers to patient and community awareness of such risks.

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